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GLP-1 / GIP receptor research · 1 articles

Tirzepatide

Tirzepatide (dual GIP/GLP-1 receptor agonist peptide; LY3298176) · 5 min read

Tirzepatide (LY3298176) is a synthetic 39-amino-acid linear peptide engineered as a single-molecule dual agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R). Its sequence is derived from the native GIP backbone and incorporates two 2-aminoisobutyric acid (Aib) substitutions, a C-terminal amide, and a C20 fatty-diacid moiety attached to the Lys20 side chain through a γ-glutamate / di-AEEA linker. It is offered strictly as a characterized reference material for in-vitro and analytical research. For Research Use Only — not for human or veterinary use.

Molecular identity

A 39-residue linear peptide with the molecular formula C₂₂₅H₃₄₈N₄₈O₆₈ and a monoisotopic/average molecular weight of approximately 4813.5 g/mol (CAS 2023788-19-2; PubChem CID 156588324). The sequence carries 2-aminoisobutyric acid (Aib) at positions 2 and 13 and a C-terminal amide.

Structural features

The Lys20 side chain is conjugated to a 1,20-eicosanedioic (C20) fatty diacid through a glutamic-acid spacer and two (2-(2-aminoethoxy)ethoxy)acetic acid (AEEA) units. This lipidation is discussed in the literature as the basis for albumin association, while the Aib substitutions are associated with resistance to dipeptidyl-peptidase cleavage in characterization studies.

Research context

In published in-vitro work, Tirzepatide is examined as a tool for probing simultaneous engagement of two incretin receptors (GIPR and GLP-1R) and the associated G-protein-coupled signaling, including comparative cAMP-response and receptor-binding assays relative to native incretins and single-target agonists.

Handling as a reference material

Supplied as a lyophilized powder at ≥98% (HPLC) purity for laboratory analytical and receptor-assay applications. Identity and purity are appropriate for use as an analytical reference standard. For Research Use Only; not intended for any in-vivo, diagnostic, or therapeutic application.

Credible sources

Research context only. This article summarizes published in-vitro and pre-clinical research for scientific context. It is not a claim of efficacy or safety and does not constitute medical, usage, or dosing guidance. Helix Reagents products are Research Use Only and not for human or veterinary use.