An introduction to GHK-Cu, the copper-binding tripeptide reference material studied in matrix-biology research.
What it is
GHK-Cu, or Copper Tripeptide-1, is a research-use-only reference material consisting of the tripeptide Gly-His-Lys complexed with copper(II). It is catalogued under the matrix-biology category and identified analytically by CAS number 89030-95-5, the formula C14H24N6O4Cu, and a molecular weight near 403.9 g/mol with a high purity specification.
The copper complex
The defining feature of GHK-Cu is the coordination of a copper(II) ion by the histidine-containing tripeptide. This metal-peptide complex gives the material its characteristic blue color and distinguishes it analytically from the free GHK peptide, which is colorless. The complex is central to the reagent's identity.
Why it is studied
GHK-Cu has a large dermatology and extracellular-matrix research literature, where it is examined in connection with collagen and elastin expression and broader gene-expression modulation in cultured systems. As a reference supplier we describe these research areas without making any applied or efficacy claim.
Collection scope
The articles here cover the coordination chemistry and stability of the complex, the matrix-biology mechanisms studied in research, the analytical methods used to characterize identity and purity, and a literature roundup with search-based sources, all within an in-vitro reference frame.